Transcranial Pulse Stimulation for Alzheimer's Disease
Recruiting · NCT07143734 · Interventional (participants receive a specific treatment) · Lead sponsor: Chinese University of Hong Kong
View the official record on ClinicalTrials.gov →Interventions studied
transcranial pulse stimulation (TPS)transcranial pulse stimulation (TPS-Sham)
What this trial is about
TPS is a non-invasive therapeutic modality that uses focused, low-energy pulse stimulation to stimulate tissue regeneration and reduce inflammation. In the context of neurological disorders, it is hypothesized that TPS can modulate neuronal activity, enhance synaptic plasticity, and reduce neuroinflammation. It is a relatively new application in neurological disease treatment and is still under intense investigation.
Who can take part
Age range
60 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Adults who have been clinically diagnosed with Alzheimer's Disease in the early stage 2-6a according to the Functional Assessment Staging Test (In Appendix A)
- The mental capacity to give informed consent for research is made by an experienced geriatrician based on Appendix A.
- Aged 60-90 years old.
- Able to make informed consent under assistance, which is witnessed and signed by a family caregiver.
Exclusion criteria
- Cannot understand Chinese.
- Mentally incapacitated, unable to provide informed consent
- Inability to remain still for 30 minutes
- Lack of available family caregiver to answer questionnaires
- Alcohol or substance dependence
- Major neurological conditions, including:
- Brain tumor
- Brain aneurysm
- Presence of any metal implants in the brain
- Hemophilia or other blood clotting disorders
- History of thrombosis
Where it is running
1 location listed.
- Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese UNiversity of Hong Kong - Hong Kong, Hong Kong