Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD
Recruiting · NCT07153692 · Interventional (participants receive a specific treatment) · Lead sponsor: Wang Ping
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment). Assessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions/networks. Correlations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.
Who can take part
Inclusion criteria
- Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy;
- VFSS examination indicates dysphagia;
- Mini-Mental State Examination (MMSE) score \>23;
- Willing to cooperate with the study and sign the informed consent form;
Exclusion criteria
- Comorbid with other diseases that cause dysphagia;
- Comorbid with pneumonia, or severe cardiac/renal insufficiency;
- Having metal implants in the body
- With cognitive impairment or inability to cooperate.
Where it is running
1 location listed.
- Second Affiliated Hospital of Zhejiang University School of Medicine - Hangzhou, Zhejiang, China