RAPART in Locally Advanced Non-small Cell Lung Cancer Patients
Recruiting · NCT07164885 · Interventional (participants receive a specific treatment) · Lead sponsor: Capital Medical University
View the official record on ClinicalTrials.gov →Interventions studied
Conventional radiotherapyRadiosensitivity-Assisted Personalized Adaptive Radiotherapy Technology（RAPART)）
What this trial is about
This is a Phase II/III randomized clinical trial of Radiosensitivity-Assisted Personalized Adaptive Radiotherapy Technology (RAPART) in locally advanced non-small cell lung cancer patients. The main objective is to test the overall improvement of overall survival (OS), progression free survival (PFS), and local progression free survival (LPFS) of unresectable stage III NSCLC under standard and non-standard mixed treatment conditions compared to conventional 60Gy radiotherapy.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Adult research participants, aged over 18 years old;
- Non small cell lung cancer that requires pathological confirmation;
- All stage 3 unresectable non-small cell lung cancer, including stage correction after MDT and stage downgrading after treatment (4 → 3), and stage upregulation due to disease progression (2 → 3);
- ECOG physical condition is 0-2;
- In addition to study participants who have not received any treatment, study participants who have undergone surgery, chemotherapy, immunotherapy, and targeted therapy are also eligible for enrollment.
Exclusion criteria
- Prisoners who are not convenient for close clinical follow-up;
- Study participants with contraindications to radiation therapy.
Where it is running
1 location listed.
- University of Hong Kong Shenzhen Hospital - Shenzhen, Guangdong, China