Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.
Recruiting · NCT07169656 · Observational (researchers observe without assigning treatment) · Lead sponsor: The First Affiliated Hospital of Zhengzhou University
View the official record on ClinicalTrials.gov →Interventions studied
ETV,TDF,TAF,TMFPeginterferon α-2b injection
What this trial is about
This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- 1.Chronic HBV infection (HBsAg-positive for ≥6 months); 2.Age ≥18 years; 3.Patients who, based on real-world clinical practice needs, are planned or currently receiving treatment with:Entecavir (ETV),Tenofovir disoproxil fumarate (TDF),Tenofovir alafenamide fumarate (TAF),Tenofovir amibufenamide (TMF) OR Pegylated interferon α-2b-naïve patients OR Patients re-initiating pegylated interferon α-2b therapy; 4.Written informed consent obtained from the patient.
Exclusion criteria
- 1.Severe hepatic dysfunction or decompensated cirrhosis; 2.Concurrent participation in other clinical trials; 3.Hepatocellular carcinoma (HCC).
Where it is running
60 locations listed.
- Huaxian People's Hospital - Anyang, China
- Linzhou City People's Hospital - Anyang, China
- Neihuang County People's Hospital - Anyang, China
- Tangyin County People's Hospital - Anyang, China
- The Fifth People's Hospital of Anyang - Anyang, China
- The First Affiliated Hospital of Xinxiang Medical University (Hua County Branch) - Anyang, China
- Guangzhou First People's Hospital - Guangzhou, China
- The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital) - Guangzhou, China
- Hebi Coal Mining Group General Hospital - Hebi, China
- Hebi Infectious Disease Hospital - Hebi, China
- Junxian County People's Hospital - Hebi, China
- Bo'ai County People's Hospital - Jiaozuo, China
- Mengzhou Hospital of Traditional Chinese Medicine - Jiaozuo, China
- Qinyang People's Hospital - Jiaozuo, China
- The Secend People's Hospital of Jiaozuo - Jiaozuo, China
- The Third People's Hospital of Jiaozuo - Jiaozuo, China
- Xiuwu People's Hospital - Jiaozuo, China
- Wenxian People's Hospital - Jiayuguan, China
- Jiyang County Hospital of Traditional Chinese Medicine - Jinan, China
- Shandong Public Health Clinical Center - Jinan, China
- Jiyuan People's Hospital - Jiyuan, China
- Jiyuan Traditional Chinese Medicine Hospital - Jiyuan, China
- Huaihe Hospital of Henan University - Kaifeng, China
- Infectious Diseases Hospital of Kaifeng - Kaifeng, China
- Kaifeng Central Hospital - Kaifeng, China
- Kaifeng Hospital of Traditional Chinese Medicine - Kaifeng, China
- Lankao First Hospital Group - Kaifeng, China
- Qixian People's Hospital - Kaifeng, China
- The People's Hospital of Weishi - Kaifeng, China
- Tongxu County People's Hospital - Kaifeng, China
- Weishi County People's Hospital - Kaifeng, China
- Linyi Hospital of Traditional Chinese Medicine - Linyi, China
- Linyi People's Hospital - Linyi, China
- Linying County People's Hospital - Luohe, China
- Luohe Central Hospital - Luohe, China
- Luanchuan County People's Hospital - Luoyang, China
- Luoning County People's Hospital - Luoyang, China
- Luoyang Central Hospital - Luoyang, China
- Luoyang First People's Hospital - Luoyang, China
- Luoyang Third People's Hospital - Luoyang, China
- Ruyang County People's Hospital - Luoyang, China
- The First Affiliated Hospital of Henan University of Science and Technology - Luoyang, China
- Xin'an County People's Hospital - Luoyang, China
- Yichuan County Hospital of Traditional Chinese Medicine - Luoyang, China
- Yiyang County People's Hospital - Luoyang, China
- Dengzhou Central Hospital - Nanyang, China
- Dengzhou People's Hospital - Nanyang, China
- Fangcheng County People's Hospital - Nanyang, China
- Nanyang Central Hospital - Nanyang, China
- Nanyang First People's Hospital - Nanyang, China
- Nanyang Oilfield General Hospital - Nanyang, China
- Nanyang Second General Hospital - Nanyang, China
- Nanzhao County People's Hospital - Nanyang, China
- Neixiang County People's Hospital - Nanyang, China
- Sheqi County People's Hospital - Nanyang, China
- Tanghe County People's Hospital - Nanyang, China
- The First Affiliated Hospital of Nanyang Medical College - Nanyang, China
- Xinye County People's Hospital - Nanyang, China
- Xixia County People's Hospital - Nanyang, China
- Zhenping People's Hospital - Nanyang, China
Showing 60 of 162 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →