7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)

Recruiting · NCT07175077 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Missouri-Columbia

Interventions studied

7t MRI

Comparison of a 7t MRI to standard of care 1.5t/3t MRI scans to determine if earlier detection of brain metastases are possible on a 7t.

Age range

18 Years and older

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not specified

Study type

Observational (researchers observe without assigning treatment)

Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC). • Patient must have an MRI of the brain, performed within 4 weeks prior to consent, documenting no evidence of brain metastases or leptomeningeal disease.
Patient also must not have a history of brain metastases or leptomeningeal disease.
Patient must refuse PCI and agree to surveillance with brain MRI scans (1.5T/3T).
Patient must be ≥ 18 years of age.
Patient must have ECOG Performance Status of 0-2
Patients must be able to tolerate the 7T MRI

Patient must not have a contraindication to an MRI, such as implanted metal devices or foreign bodies.
Patient must not have a contraindication to gadolinium contrast administration during MR imaging.
Patient must not have other metastatic malignancies requiring current active treatment.
Pregnant patients are excluded. Pregnancy status will be confirmed verbally.

1 location listed across 1 US state.