Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment
Recruiting · NCT07226947 · Interventional (participants receive a specific treatment) · Lead sponsor: Massachusetts General Hospital
View the official record on ClinicalTrials.gov →Interventions studied
General guidance on recommended exerciseSmartwatch activity and body composition monitor
What this trial is about
The goal of this study is to learn if a smartwatch that measures activity level and body composition, combined with exercise reminders, can safely improve strength and muscle mass in people who recently started or are planning to start treatment with incretin therapy (liraglutide, semaglutide, tirzepatide or retatrutide), also known as glucagon-like peptide 1 receptor agonist (GLP-1 RA) medications.
Who can take part
Age range
18 Years to 99 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 18 years old at time of signing informed consent
- Started treatment with incretin therapy (liraglutide, semaglutide, tirzepatide, or retatrutide) within the past 2 months or planning to start this treatment
- a. Potential participants switching GLP1-RA therapies due to inadequate response to a prior treatment will be eligible for enrollment
- Able to provide informed consent
Exclusion criteria
- Current pregnancy (positive urine hCG) or plans to become pregnant in the next 6 months
- BMI \<25 kg/m2 at the time of screening
- Unable to participate in a regular physical exercise program
- Implanted pacemaker
- Any factors that, in the opinion of the principal investigator, would interfere with the safe completion of the study
Where it is running
1 location listed across 1 US state.
- Diabetes Research Center - Boston, Massachusetts, United States