Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department
Recruiting · NCT07228052 · Interventional (participants receive a specific treatment) · Lead sponsor: Montefiore Medical Center
View the official record on ClinicalTrials.gov →Interventions studied
Dexamethasone 16mg IMPrednisone 60mg PO
What this trial is about
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Adults ≥18 years old presenting to the ED with an asthma exacerbation
- Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
- Discharged from the ED with a primary diagnosis of asthma exacerbation
- Initiated systemic corticosteroids during the ED visit
- Must be English or Spanish speaking
Exclusion criteria
- Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival
- History of severe adverse reactions to corticosteroids
- Heart failure and uncontrolled diabetes (glucose \>300mg/dL in the ED)
- Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population
- Inability to provide informed consent
Where it is running
1 location listed across 1 US state.
- Montefiore Medical Center - The Bronx, New York, United States