Effects of Grape Consumption on the Immune-Gut Axis in Obesity
Recruiting · NCT07231484 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Missouri-Columbia
View the official record on ClinicalTrials.gov →Interventions studied
Freeze-dried grape powderPlacebo powder
What this trial is about
This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.
Who can take part
Age range
18 Years to 60 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age: 18-60 years
- Obesity with BMI of 30-45 kg/m2
- Willingness to consume study foods
- Consistent diet and activity patterns for 4 weeks
- Weight stable (\<5kg change over last 3 months)
- Non-smoker \> 1 year or more
- Not currently consuming an extremely healthy diet
Exclusion criteria
- Study food allergies
- Regular consumption of grapes or grape-derived products
- Gastrointestinal disease and/or bariatric surgery
- Uncontrolled hypertension and blood pressure \>180/110
- Diabetes
- Illicit drug use
- History of alcohol or drug abuse
- Recent use of medications that affect immune function (e.g., corticosteroids)
- Recent consumption of antibiotics, prebiotics, probiotics, symbiotics, or dietary supplements containing fiber or phytochemicals
- Pregnant or lactating individuals
- HIV positivity
- Recent start of medications that affect metabolism or appetite
- Drug therapy for coronary artery disease, peripheral artery disease, congestive
Where it is running
1 location listed across 1 US state.
- University of Missouri-Columbia - Columbia, Missouri, United States