Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia
Recruiting · NCT07245056 · Interventional (participants receive a specific treatment) · Lead sponsor: Ankara Etlik City Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Since early-onset preeclampsia (EOPE) is commonly associated with inadequate placentation, placental insufficiency, chronic fetal hypoxia, oxidative stress, and heightened inflammation, these pathological processes may adversely affect hippocampal neuronal development and maturation of axonal pathways such as the fornix. These mechanisms support our hypothesis that fetal fornix and hippocampus dimensions may be reduced in pregnancies complicated by EOPE, forming the scientific basis of our study. Previous research has suggested a potential link between preeclampsia (PE) and altered neurocognitive development. However, no studies to date have specifically evaluated the relationship between EOPE and fetal fornix or hippocampus dimensions. Therefore, the objective of our study is to assess fetal fornix and hippocampus measurements in pregnant women with early-onset preeclampsia compared with healthy controls.
Who can take part
Inclusion criteria
- Women aged 18-45 years
- Gestational age between 20 and 34 weeks
- Diagnosis of early-onset preeclampsia (EOPE)
- Singleton pregnancy
Exclusion criteria
- Multiple pregnancies
- Presence of chronic or significant comorbid conditions other than maternal early-onset preeclampsia, including: Chronic, mental, or physical illnesses, severe renal, hepatic, or gastrointestinal acute or chronic inflammatory diseases, hyperthyroidism or hypothyroidism, chronic hypertension, type 1 or type 2 diabetes mellitus, history of polycystic ovary syndrome (PCOS), history of malignancy
- Fetal congenital or chromosomal anomalies
- Chronic medication use
- Tobacco or alcohol use during pregnancy
- Maternal late-onset preeclampsia (≥34 weeks gestation)
Where it is running
1 location listed.
- Ankara Etlik City Hospital - Ankara, Yenimahalle, Turkey (Türkiye)