Metabolic Fluid Responsiveness in Children
Recruiting · NCT07255469 · Observational (researchers observe without assigning treatment) · Lead sponsor: University Hospital, Bordeaux
View the official record on ClinicalTrials.gov →What this trial is about
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.
Who can take part
Inclusion criteria
- Age less than or equal to 15 years old
- Hospitalization in a pediatric intensive care unit after cardiac surgery
- Prescription by the attending physician of a fluid expansion of 10ml/kg
- Prescription of arterial and venous blood gas before and after the volume expansion to help manage acute circulatory failure
- Patient implanted with a functioning arterial line
- Patient implanted with a functioning central venous line in the superior vena cava territory
Exclusion criteria
- Patient less than 37 weeks' corrected gestational age
- Hemodynamic instability making the delay necessary for any test dangerous
- Supine position contraindicated or deleterious
- Impairment of echocardiographic acoustic window or restless patient making ultrasonography impossible
- Opposition to participate expressed by the patient or by a parent or legal guardian
Where it is running
8 locations listed.
- Hôpital Louis Pradel - Hospices Civils de Lyon - Bron, France, France
- Hôpital Jeanne de Flandre - CHU de Lille - Lille, France, France
- Hôpital de la Timone - Assistance Publique - Hôpitaux de Marseille - Marseille, France, France
- Hôpital mère-enfant - CHU de Nantes - Nantes, France, France
- Hôpital Necker-Enfants Malades - Assistance Publique - Hôpitaux de Paris - Paris, France, France
- Hôpital Cardiologique Haut Lévêque - CHU de Bordeaux - Pessac, France, France
- Hôpital des enfants - CHU de Toulouse - Toulouse, France, France
- Hôpital Felix Guyon - CHU de la Réunion - Saint-Denis, La Réunion, France