Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOS
Recruiting · NCT07255911 · Interventional (participants receive a specific treatment) · Lead sponsor: Mst.Sumyara Khatun
View the official record on ClinicalTrials.gov →Interventions studied
Cabergoline 0.5 mgLetrozole 0.5mg
What this trial is about
Does combined Cabergoline and letrozole increase ovulation rate What medical problems do participants have when taking drug Cabergoline and Letrozole ? Researchers will compare drug combination of Cabergoline and letrozole to letrozole alone to see combined cabergoline and letrozole works better as ovulation induction. Participants will: experimental group will receive Cabergoline and Letrozole comparator group will receive letrozole alone TVS Monitoring will be done for 3 cycle for ovarian response
Who can take part
Age range
18 Years to 35 Years
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- PCOS patients diagnosed according to Rotterdam criteria.
- Age: 18-35 years.
- Primary or secondary subfertility.
- Selected for ovulation induction.
Exclusion criteria
- Women suffered from PCOS like symptom ex. Late onset congenital adrenal hyperplasia, Cushing syndrome.
- Serum prolactin (more than 50 ng/ml) (Kyritsi et al., 2018).
- Male factor infertility.
- Women with other infertility factors (endometriosis, PID,uterine \& tubal causes of infertility).
- Uncontrolled Medical disease (DM, HTN, kidney disease, liver disease).
- History of hypersensitivity to cabergoline \& letrozole.
- Thyroid dysfunction ( serum TSH ≥5mIU/L)
- BMI:\< 18.5 kg/m2 and ≥30 kg/m2.
- Patients on metformin therapy.
- Patient on antiemetic like Domperidone metoclopramide, antipsychotic drug like haloperidol and risperidone, tricyclic antidepressant like amitriptyline, clomipramine, antihypertensive like verapamil, methyldopa, reserpine.
Where it is running
1 location listed.
- Bangladesh Medical University - Dhaka, Shahbag, Bangladesh