Comparison Between Oral Methotrexate and Tofacitinib in Chronic Plaque Psoriasis
Recruiting · NCT07261306 · Interventional (participants receive a specific treatment) · Lead sponsor: Lahore General Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Psoriasis is a chronic inflammatory dermatoses which include well demarcated scaly erythematous plaques on whole body including scalp role of methotrexate vs tofacitinib is compared in this study
Who can take part
Age range
18 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Early Phase 1
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients aged 18- 70 years of either gender.
- Only patients with Psoriasis Area and Severity Index (PASI) score of 10 or above, and/or Body Surface Area (BSA) involvement of 10% or more, will be included.
- Duration of plaque psoriasis for at least 6 months prior to the study.
- Psoriasis that has not shown adequate response to topical therapies
Exclusion criteria
- Individuals with other forms of psoriasis or other significant dermatological conditions that might interfere with the assessment of psoriasis.
- Participants currently receiving systemic corticosteroids, biologics, or any other immunosuppressive agents within 4 weeks prior to the start of the study will be excluded.
- Known hypersensitivity or contraindications to either methotrexate or tofacitinib.
- History of significant liver, kidney, hematologic/bleeding disorder, gastrointestinal/acid peptic disease, or immune system disorders.and any history of tuberculosis and malignancy.
- Pregnant or lactating women will not be eligible for the study.
Where it is running
1 location listed.
- Lahore general hospital - Lahore, Punjab Province, Pakistan