A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Recruiting · NCT07274631 · Observational (researchers observe without assigning treatment) · Lead sponsor: CHU de Reims
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are characterised by lung inflammation and remodelling. Clinical, functional, microbiological, biological, pathological and prognostic features are highly variable and heterogeneous. Several phenotypes have been described within the same pathology, as similar phenotypic traits between different pathologies, or the coexistence of components of several diagnoses in the same patient, suggesting shared underlying mechanisms that could represent new therapeutic targets, beyond the initial medical diagnosis. The objectives of this prospective study are to analyze the phenotypic characteristics (clinical, demographic, biological, morphological, pathological, and microbiological characteristics) together with respiratory exposures and underlying mechanisms involving airway epithelium and inflammation processes in a cohort of patients diagnosed with asthma, COPD, bronchiectasis, CF, PCD and ILD.
Who can take part
Inclusion criteria
- Age ≥ 18 years
- Follow-up for one of the following conditions: asthma, COPD, bronchiectasis (DDB), cystic fibrosis (CF), primary ciliary dyskinesia (PCD), or interstitial lung diseases (ILD)
- Healthy volunteers (controls)
Exclusion criteria
- Subjects protected by law (e.g., legal incapacity)
- Any condition preventing informed consent or participation
Where it is running
2 locations listed.
- Chu Reims - Reims, France
- Chu Reims - Reims, France