TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%
Recruiting · NCT07279402 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →What this trial is about
This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell expression ≥50% and no targetable mutations. The study aim to determine how atezolizumab performs in routine clinical practice with respect to survival, treatment response, and safety outcomes in this patient population in Türkiye.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Signed informed consent form.
- Diagnosis of stage IV non-small cell lung cancer.
- Male or female patients aged 18 years or older.
- Patients who have been prescribed atezolizumab in accordance with routine clinical practice and the locally approved indication in Türkiye.
- Patients who have received up to 3 cycles of atezolizumab at the screening visit.
Exclusion criteria
- Patients who are not receiving atezolizumab for the treatment of lung cancer according to standard of care and the approved indication.
- Known or suspected hypersensitivity to atezolizumab.
- Pregnant or breastfeeding women.
Where it is running
25 locations listed.
- Adana City Hospital - Adana, Turkey (Türkiye)
- Afyonkarahisar Health Sciences University Hospital - Afyonkarahisar, Turkey (Türkiye)
- Ankara Oncology Training and Research Hospital - Ankara, Turkey (Türkiye)
- Memorial Ankara Hospital - Ankara, Turkey (Türkiye)
- Ankara Bilkent City Hospital - Ankara, Turkey (Türkiye)
- Ankara Atatürk Sanatoryum Training and Research Hospital - Ankara, Turkey (Türkiye)
- Antalya Training and Research Hospital - Antalya, Turkey (Türkiye)
- Antalya City Hospital - Antalya, Turkey (Türkiye)
- Adnan Menderes University Faculty of Medicine Hospital - Aydin, Turkey (Türkiye)
- Dicle University Hospital - Diyarbakır, Turkey (Türkiye)
- Trakya University Faculty of Medicine Hospital - Edirne, Turkey (Türkiye)
- Gaziantep City Hospital - Gaziantep, Turkey (Türkiye)
- Bahçelievler Memorial Hospital - Istanbul, Turkey (Türkiye)
- İstanbul Medipol Mega Hospital - Istanbul, Turkey (Türkiye)
- Ümraniye Training and Research Hospital - Istanbul, Turkey (Türkiye)
- Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi - Istanbul, Turkey (Türkiye)
- Başakşehir Çam and Sakura City Hospital - Istanbul, Turkey (Türkiye)
- Dokuz Eylul University Faculty of Medicine Hospital - Izmir, Turkey (Türkiye)
- Ege University Hospital - Izmir, Turkey (Türkiye)
- Necmettin Erbakan University Meram Faculty of Medicine Hospital - Konya, Turkey (Türkiye)
- Mersin University Faculty of Medicine Hospital - Mersin, Turkey (Türkiye)
- Ordu State Hospital - Ordu, Turkey (Türkiye)
- Sakarya University Faculty of Medicine Hospital - Sakarya, Turkey (Türkiye)
- Medical Park Samsun Hospital - Samsun, Turkey (Türkiye)
- Karadeniz Technical University Farabi Hospital - Trabzon, Turkey (Türkiye)