Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease

Recruiting · NCT07285642 · Interventional (participants receive a specific treatment) · Lead sponsor: Saglik Bilimleri Universitesi

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Copd

Interventions studied

Aerobic Exercise (Treadmill Walking)Breathing ExercisesCognitive Task (Stroop Task)Resistance Exercise (Upper and Lower Limb Strength Training)

What this trial is about

This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD). Functional near-infrared spectroscopy (fNIRS) and near-infrared spectroscopy (NIRS) will be used simultaneously to measure oxygenation changes in the prefrontal cortex and the vastus lateralis muscle during rest, Stroop task performance, the six-minute walk test, aerobic, strengthening, and breathing exercises. The study will compare COPD patients and age- and sex-matched healthy controls to determine how brain and muscle oxygenation responses differ between groups and among exercise modalities. The findings are expected to guide the design of safe, individualized pulmonary rehabilitation programs that optimize oxygenation without compromising safety.

Who can take part

Age range

40 Years to 70 Years

Sex

All (male and female)

Healthy volunteers

Yes - healthy volunteers may be accepted

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

Age 40-70 years
Diagnosis of moderate-to-severe COPD (GOLD stage II-III)
Stable disease (no exacerbation in previous 4 weeks)
BMI 18.5-24.9 kg/m²
Manual muscle strength ≥ 4 (MRC scale)
Ability to perform exercise tests safely
Written informed consent

Exclusion criteria

Severe comorbid conditions (uncontrolled cardiac, neurological, or orthopedic disease)
Need for high-flow oxygen therapy (\>2 L/min)
History of cerebrovascular disease or transient ischemic attack
Musculoskeletal or dermatological conditions impairing NIRS measurement sites
Restrictive lung disease, interstitial lung disease, or small-airway disease
Participation in an exercise program within the last 12 months
Healthy Controls
Age 40-70 years
No acute or chronic disease
Non-smoker
BMI 18.5-24.9 kg/m²
No musculoskeletal limitations

Where it is running

1 location listed.

Esra Pehlivan - Istanbul, Turkey (Türkiye)

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →