Exploring the Effects of Exercise Combined With BFRT on Healthy and Patients With CKD
Recruiting · NCT07288905 · Interventional (participants receive a specific treatment) · Lead sponsor: National Cheng Kung University
View the official record on ClinicalTrials.gov →Interventions studied
Aerobic exerciseBlood flow restrictionDisease and exercise suggestionResistance exercise
What this trial is about
Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in healthy and CKD patients
Who can take part
Age range
20 Years to 85 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Aged 20\~85 years old
Exclusion criteria
- Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)
- Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
- Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
- Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
- Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
- Prone to bruising
- Recent inflection \< 1 month
- Pregnancy
- Kidney function impairment
- Cancer
- Simultaneously participating in other research
- CKD
- Inclusion criteria:
- Aged 20\~85 years old
- eGFR\< 90 ml/min/1.73 m2 over 3 months
- Stable condition without worsening in the past 3 months
- Ability to understand and follow verbal commends and cooperate with an exercise training program
- Exclusion criteria:
- Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)
- Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
- Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
- Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
- Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
- Abnormal blood biochemical parameters (e.g., white blood cell count \<2500/mm³, hemoglobin \<8 mg/dL, total bilirubin \>3 mg/dL, liver enzymes (GOT/AST, GPT/ALT) \>3 times the upper limit of normal, platelet count \<75,000/mm³
- Sensory or motor dysfunctions that affect walking ability
- Diagnosed systemic diseases under ongoing treatment (e.g., systemic lupus erythematosus, cancer, malignancies).
Where it is running
1 location listed.
- National Cheng Kung University Hospital - Tainan, Taiwan