A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Recruiting · NCT07321886 · Interventional (participants receive a specific treatment) · Lead sponsor: Eli Lilly and Company

View the official record on ClinicalTrials.gov →

Type 2 diabetes Obesity

Interventions studied

EloralintidePlacebo

What this trial is about

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.

Who can take part

Age range

18 Years and older

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Phase 3

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

Have Body Mass Index (BMI) at screening of the following:
30 kilogram per square meter (kg/m2) OR
27 kg/m2 with at least one of the following weight-related health conditions at screening:
high blood pressure
dyslipidemia
obstructive sleep apnea, or
heart disease
Have a stable body weight (\<5% body weight change) for 90 days prior to screening.
Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight

Exclusion criteria

Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
Have type 1 diabetes or type 2 diabetes
Have had within 90 days prior to screening:
heart attack
stroke
coronary artery revascularization
unstable angina, or
hospitalization due to congestive heart failure
Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Where it is running

60 locations listed across 23 US states.

MFA Clinical Research - Tuscaloosa, Alabama, United States
MFA Clinical Research - Tuscaloosa, Alabama, United States
Headlands Research - Scottsdale - Scottsdale, Arizona, United States
Headlands Research - Scottsdale - Scottsdale, Arizona, United States
Neighborhood Healthcare Institute of Health - Escondido, California, United States
Neighborhood Healthcare Institute of Health - Escondido, California, United States
Ark Clinical Research - Fountain Valley - Fountain Valley, California, United States
Ark Clinical Research - Fountain Valley - Fountain Valley, California, United States
Desert Oasis Healthcare Medical Group - Palm Springs, California, United States
Desert Oasis Healthcare Medical Group - Palm Springs, California, United States
Peninsula Research Associates - Rolling Hills Estates, California, United States
Peninsula Research Associates - Rolling Hills Estates, California, United States
Care Access - Sacramento - Sacramento, California, United States
Care Access - Sacramento - Sacramento, California, United States
Southern California Clinical Research - Santa Ana, California, United States
Southern California Clinical Research - Santa Ana, California, United States
University Clinical Investigators, Inc. - Tustin, California, United States
University Clinical Investigators, Inc. - Tustin, California, United States
Chase Medical Research, LLC - Waterbury, Connecticut, United States
Chase Medical Research, LLC - Waterbury, Connecticut, United States
JEM Research Institute - Atlantis, Florida, United States
JEM Research Institute - Atlantis, Florida, United States
BioMed Research & Medical Center - Miami, Florida, United States
BioMed Research & Medical Center - Miami, Florida, United States
Adult Medicine of Lake County, Inc. - Mt. Dora, Florida, United States
Adult Medicine of Lake County, Inc. - Mt. Dora, Florida, United States
American Research Centers of Florida - Pembroke Pines, Florida, United States
American Research Centers of Florida - Pembroke Pines, Florida, United States
AHF Pensacola - Pensacola, Florida, United States
AHF Pensacola - Pensacola, Florida, United States
IMA Clinical Research St. Petersburg - St. Petersburg, Florida, United States
IMA Clinical Research St. Petersburg - St. Petersburg, Florida, United States
Teak Research Consults - Dunwoody - Dunwoody, Georgia, United States
Teak Research Consults - Dunwoody - Dunwoody, Georgia, United States
Teak Research Consults - Lawrenceville, Georgia, United States
Teak Research Consults - Lawrenceville, Georgia, United States
Clinical Research Atlanta - Stockbridge, Georgia, United States
Clinical Research Atlanta - Stockbridge, Georgia, United States
East-West Medical Research Institute - Honolulu, Hawaii, United States
East-West Medical Research Institute - Honolulu, Hawaii, United States
Iowa Diabetes and Endocrinology Research Center - West Des Moines, Iowa, United States
Iowa Diabetes and Endocrinology Research Center - West Des Moines, Iowa, United States
Cotton O'Neil Clinical Research Center - Topeka, Kansas, United States
Cotton O'Neil Clinical Research Center - Topeka, Kansas, United States
Care Access - Lake Charles (Bayou Pines) - Lake Charles, Louisiana, United States
Care Access - Lake Charles (Bayou Pines) - Lake Charles, Louisiana, United States
MedStar Good Samaritan Hospital - Baltimore, Maryland, United States
MedStar Good Samaritan Hospital - Baltimore, Maryland, United States
MedStar Health Research Institute (MedStar Physician Based Research Network) - Hyattsville, Maryland, United States
MedStar Health Research Institute (MedStar Physician Based Research Network) - Hyattsville, Maryland, United States
Care Access - Quincy - Quincy, Massachusetts, United States
Care Access - Quincy - Quincy, Massachusetts, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division - Troy, Michigan, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division - Troy, Michigan, United States
AMR Clinical - Las Vegas, Nevada, United States
AMR Clinical - Las Vegas, Nevada, United States
IMA Clinical Research Warren - Warren Township, New Jersey, United States
IMA Clinical Research Warren - Warren Township, New Jersey, United States
Albuquerque Clinical Trials, Inc. - Albuquerque, New Mexico, United States
Albuquerque Clinical Trials, Inc. - Albuquerque, New Mexico, United States

Showing 60 of 324 listed sites. See the official record for the complete list.

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →