Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies
Recruiting · NCT07332234 · Observational (researchers observe without assigning treatment) · Lead sponsor: Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș"
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Timely detection of signs of raised intracranial pressure or persistent inflammation within the meninges can expedite therapeutic decisions improving the prognosis of patients with brain damage. Optic nerve ultrasonography provides a user-friendly, safe, low-cost, and non-invasive imaging method that can be easily deployed for ICU patient assessment. This study aims to evaluate the sensitivity and specificity of optic nerve ultrasound in estimating cerebral inflammation extension and cerebral edema in patients in the ICU. The working hypothesis is that optic nerve ultrasound is a useful tool in the rapid diagnosis of cerebral edema and the presence or persistence of cerebral inflammation, which can enable adapted and rapid therapeutic interventions.
Who can take part
Inclusion criteria
- Patients admitted into one of the specified wards of the involved hospitals
- Patients aged 18-60 years
- Suspected meningitis, encephalitis, stroke or cerebral tumors
Exclusion criteria
- Age under 18 years or over 60 years old
- Ocular lesions preventing ocular ultrasound (palpebral infections, cornean erosions, glaucoma, trauma)
- Conditions preventing lumbar puncture (coagulation disorders, epidural abscesses, local infections)
Where it is running
2 locations listed.
- Fundeni Clinical Institute - Bucharest, Bucharest, Romania
- "Dr. Victor Babeș" Clinical Hospital for Infectious and Tropical Diseases - Bucharest, Bucharest, Romania