Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery
Recruiting · NCT07344467 · Interventional (participants receive a specific treatment) · Lead sponsor: Tanta University
View the official record on ClinicalTrials.gov →Interventions studied
Melatonin capsulePlacebo capsulePregabalin capsule
What this trial is about
This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.
Who can take part
Age range
21 Years to 60 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients aged 21-60 years old.
- Both sexes.
- Patients of American Society of Anesthesiologists (ASA) physical status I \& II.
- Undergoing elective spine surgery.
Exclusion criteria
- Patient refusal.
- History of allergic reactions to melatonin or pregabalin.
- Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block).
- Patients with kidney disease with (plasma creatinine level \> 1.5mg/dl).
- Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal).
- Psychological and cognitive disorders; dementia; major depression.
- Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness.
Where it is running
1 location listed.
- Tanta University - Tanta, El-Gharbia, Egypt