Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
Recruiting · NCT07351149 · Observational (researchers observe without assigning treatment) · Lead sponsor: Uppsala University
View the official record on ClinicalTrials.gov →What this trial is about
This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.
Who can take part
Inclusion criteria
- Elective, urgent or emergency in-patient major non-cardiac surgical procedures performed under general anaesthesia with or without regional analgesia with a planned procedure duration of at least 60 minutes.
- Paediatric patients (0-16 years old)
Exclusion criteria
- Declined participation.
- Ongoing renal replacement therapy
- Acute Kidney Injury (according to KDIGO)
- Known chronic kidney disease
- Procedure involving surgery of the kidney
- Procedures requiring clamping of blood flow to or from the kidney
- Body weight \<2kg
- Procedure involving contrast administration
- Established rhabdomyolysis (CK-levels \>1500 U/L)
Where it is running
13 locations listed.
- University Hospital Basel - Basel, Switzerland
- University Hospital of Belgrade - Belgrade, Serbia
- University Hospital Bern - Bern, Switzerland
- University Hospital Geneva - Geneva, Switzerland
- IRCCS Istituto Giannina Gaslini - Genova, Italy
- Sahlgrenska University Hospital - Gothenburg, Sweden
- Skåne University Hospital - Lund, Sweden
- Hospices Civils de Lyon - Lyon, France
- Karolinska University Hospital - Stockholm, Sweden
- Hospital das Clínicas HCFMUSP - São Paulo, Brazil
- Uppsala University Hospital - Uppsala, Sweden
- Perth Children's Hospital - Perth, Western Australia, Australia
- The Kids Research Institute Australia - Perth, Western Australia, Australia