Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
Recruiting · NCT07363343 · Interventional (participants receive a specific treatment) · Lead sponsor: The Cleveland Clinic
View the official record on ClinicalTrials.gov →Interventions studied
Nifedipine and EnalaprilNifedipine and Labetalol
What this trial is about
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
Who can take part
Age range
18 Years and older
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Postpartum women aged 18 years or older
- Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
- Taking Nifedipine 60 mg every 12 hours for blood pressure control
- Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
- English speaking
Exclusion criteria
- Taking ≥2 antihypertensive agents during pregnancy
- Heart block
- Heart rate \<60 or \>120 beats per minute
- Heart failure
- Creatinine \>1.5 mg/dL
- Renal artery stenosis
- Active connective tissue disease
- Cerebrovascular accident
- Failed treatment or contraindications to nifedipine, enalapril or labetalol
Where it is running
1 location listed across 1 US state.
- Cleveland Clinic - Cleveland, Ohio, United States