Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure
Recruiting · NCT07369856 · Interventional (participants receive a specific treatment) · Lead sponsor: Cardiology Research UBC
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Heart failure is a chronic condition that causes congestion and frequent hospitalizations. Diuretic doses are usually adjusted based on clinical judgment without an objective measure of response. This study will test the feasibility of using point-of-care urine sodium measurements to guide up-titration or down-titration of loop diuretics in ambulatory patients with heart failure. Participants will be assigned to one of three groups based on congestion status. Groups 1 and 2 will be randomized 1:1 to natriuresis-guided therapy or standard care. Group 3 will be observational. The 90-day pilot trial will evaluate feasibility, clinical outcomes, and usability of a urine sodium-guided titration strategy.
Who can take part
Inclusion criteria
- Age ≥18 years
- Diagnosis of heart failure according to the Universal Definition
- Use of loop diuretics
- Residing in VCH or PHC regions
- Group-specific inclusion:
- Group 1: Congestion score ≥5 OR objective congestion; stable furosemide ≥1 week Group 2: NYHA I-II; congestion score \<5; no recent HF hospitalization; stable furosemide ≥1 month Group 3: First 100 eligible patients not meeting criteria for Groups 1 or 2
Exclusion criteria
- eGFR \<20 mL/min/1.73m²
- Renal replacement therapy
- High-risk clinical status requiring hospitalization
- Inability to consent or perform required urine sampling
Where it is running
1 location listed.
- Vancouver General Hospital - Vancouver, British Columbia, Canada