CDK4/6 Inhibitors in Breast Cancer Elderly Patients: an Observational Ambispective Longitudinal Multicenter Study
Recruiting · NCT07399808 · Observational (researchers observe without assigning treatment) · Lead sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia
View the official record on ClinicalTrials.gov →What this trial is about
Breast cancer is one of the tumors with the highest incidence and current evidence indicates a higher prevalence in elderly patients (≥70 years) with a higher mortality rate due to immunosenescence, diagnostic delay and under treatment. Elderly patients are still poorly represented in clinical trials and the main indications for the treatment of the elderly population are extrapolated from the guidelines used in studies conducted predominantly on the younger population. In particular, these guidelines do not take into account the significant variability of elderly patients, in particular their comorbidities, performance status, physiological age and frailty. The aim of this study is to improve understanding of the clinical efficacy and safety of CDK 4/6i in older women in a real-world setting compared to younger women.
Who can take part
Inclusion criteria
- age over 18 years
- patients with solid tumours undergoing active systemic treatment with CDK4/6 for adjuvant disease
Exclusion criteria
- Patients who are unable to understand informed consent document
Where it is running
1 location listed.
- Fondazione IRCCS Policlinico San Matteo di Pavia - Pavia, Pavia, Italy