Direct vs Standard SLT for Glaucoma: A Noninferiority Trial
Recruiting · NCT07408154 · Interventional (participants receive a specific treatment) · Lead sponsor: Medical University of South Carolina
View the official record on ClinicalTrials.gov →Interventions studied
Direct Selective laser Trabeculoplasty
What this trial is about
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥18 years
- Diagnosis of OAG (including exfoliative or pigmentary) or OHT
- Gonioscopically open angle (visible scleral spur 360°)
- Ability to consent and comply with follow-up
Exclusion criteria
- Angle-closure or secondary glaucomas
- IOP \>35 mmHg despite therapy
- Corneal pathology interfering with laser or IOP measurement
- Recent ocular surgery (\<6 months)
- Contraindications to study medications or procedures
- Cognitive impairment preventing consent
Where it is running
1 location listed across 1 US state.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →