A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
Recruiting · NCT07412704 · Interventional (participants receive a specific treatment) · Lead sponsor: Bristol-Myers Squibb
View the official record on ClinicalTrials.gov →Interventions studied
BMS-986528
What this trial is about
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary evidence of disease-modifying effect of BMS-986528 in participants with refractory, difficult-to-treat rheumatoid arthritis (RA).
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 1, Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- \- Adult participants with rheumatoid arthritis (RA) who meet definition of difficult-to-treat.
Exclusion criteria
- Juvenile arthritis or onset of inflammatory arthritis before age 18.
- Seronegative RA participants in whom polymyalgia rheumatica has not been ruled out.
- Active fibromyalgia with pain symptoms or signs that would interfere with joint assessment.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Where it is running
39 locations listed across 7 US states.
- Local Institution - 0068 - La Jolla, California, United States
- Local Institution - 0070 - Loma Linda, California, United States
- Local Institution - 0069 - Palo Alto, California, United States
- Local Institution - 0050 - Aurora, Colorado, United States
- Colorado Blood Cancer Institute - Denver, Colorado, United States
- Local Institution - 0055 - South Miami, Florida, United States
- Local Institution - 0081 - New York, New York, United States
- Local Institution - 0079 - New York, New York, United States
- Local Institution - 0066 - Portland, Oregon, United States
- Local Institution - 0071 - Philadelphia, Pennsylvania, United States
- Local Institution - 0051 - DeSoto, Texas, United States
- Charité Research Organisation - Berlin, Germany
- Local Institution - 0037 - Bern, Switzerland
- Local Institution - 0021 - Cologne, Germany
- Local Institution - 0027 - Geneva, Switzerland
- Local Institution - 0028 - Herne, Germany
- Local Institution - 0049 - Leuven, Belgium
- Local Institution - 0053 - México, Mexico
- Local Institution - 0017 - Roma, Italy
- St. Josef-Stift Sendenhorst - Sendenhorst, Germany
- Local Institution - 0061 - Ternopil, Ukraine
- Local Institution - 0039 - A Coruña, A Coruña [La Coruña], Spain
- Local Institution - 0040 - München, Bavaria, Germany
- Local Institution - 0006 - Beijing, Beijing Municipality, China
- Local Institution - 0058 - Córdoba, Córdoba, Spain
- Local Institution - 0048 - Merksem, Flanders, Belgium
- Local Institution - 0083 - Aparecida de Goiânia, Goiás, Brazil
- Local Institution - 0080 - Guangzhou, Guangdong, China
- Local Institution - 0010 - Zhengzhou, Henan, China
- Local Institution - 0060 - Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine
- Local Institution - 0007 - Nanchang, Jiangxi, China
- Local Institution - 0064 - Kyiv, Kyiv Oblast, Ukraine
- Local Institution - 0023 - Józefów, Masovian Voivodeship, Poland
- Local Institution - 0019 - Rozzano, Milano, Italy
- Local Institution - 0063 - Poltava, Poltava Oblast, Ukraine
- Local Institution - 0033 - Porto Alegre, Rio Grande do Sul, Brazil
- Local Institution - 0020 - Shanghai, Shanghai Municipality, China
- Local Institution - 0001 - Shanghai, Shanghai Municipality, China
- Local Institution - 0082 - Valinhos, São Paulo, Brazil