Optic Nerve Head Strain in Non-glaucoma Subjects
Recruiting · NCT07425535 · Interventional (participants receive a specific treatment) · Lead sponsor: Johns Hopkins University
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
Who can take part
Age range
30 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Early Phase 1
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Adults who have no history of OAG
- Have an ocular examination by a glaucoma specialist with no indications of OAG
- Have normal optical coherence tomography findings in the retinal nerve fiber layer.
- Over age 30 will be included from
- Both sexes
- All ethnic groups.
- Optic neuropathy.
- Both suspects and those with glaucoma damage will be included.
- When both eyes meet inclusion and
Exclusion criteria
- , both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.
- Exclusion Criteria:
- in whom sitting in an upright position is impossible due to physical disability
- with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
- in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
- who cannot perform home tonometry accurately at certification
- who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
- with any form of glaucoma
- with high myopia defined as refractive error \> -8
- with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret
- inability to understand English or with a language or hearing impairment
Where it is running
1 location listed across 1 US state.
- Johns Hopkins Hospital - Baltimore, Maryland, United States