German Dementia Registry
Recruiting · NCT07433010 · Observational (researchers observe without assigning treatment) · Lead sponsor: RWTH Aachen University
View the official record on ClinicalTrials.gov →Interventions studied
This is a registry.
What this trial is about
The German Dementia Registry (DEMREG) is a large-scale national prospective biomarker-based study for cognitive impairment and dementia, providing an integrated clinical research platform for research studies.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Inclusion Criteria for Patient:
- Ability of the participant and/or his/her legally authorized representative (e.g., spouse or legal guardian), as appropriate and applicable, to understand the purpose and risks of the register and provide signed and dated informed consent and authorization to use protected health information (PHI) in accordance with national and local privacy regulations.
- Participating patients must have a diagnosis of SCD, MCI or early dementia of different etiology (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy-Body Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Normal Pressure Hydrocephalus, Major Depression; Vascular Dementia; TDP-43 associated limbic encephalopathy (LATE), Mixed Dementia AD + VaD, Prion-Associated Dementia) together with biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.
- At least 18 years of age.
- Inclusion Criteria for family member:
- At least 18 years of age.
- Patient was included in the registry
- Family member is strongly involved to the patient's life according to the patient's statement
- Ability of the participant, as appropriate and applicable, to understand the purpose and risks of the register
Exclusion criteria
- Exclusion Criteria for Patient:
- Unwilling to provide informed consent.
- No available biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.
- Exclusion Criteria for family member:
- Unable or unwilling to provide informed consent.
Where it is running
24 locations listed.
- Heidelberg University Hospital - Heidelberg, Baden-Wurttemberg, Germany
- ZI Mannheim - Mannheim, Baden-Wurttemberg, Germany
- University Hospital Tübingen - Tübingen, Baden-Wurttemberg, Germany
- Ulm University Hospital - Ulm, Baden-Wurttemberg, Germany
- Universitätsklinikum Erlangen - Erlangen, Bavaria, Germany
- Klinikum Frankfurt (Oder) - Frankfurt (Oder), Brandenburg, Germany
- Immanuel Klinik Rüdersdorf - Rüdersdorf, Brandenburg, Germany
- Klinikum Bremen-Ost - Bremen, Free Hanseatic City of Bremen, Germany
- Medical Center Hamburg-Eppendorf - Hamburg, Free and Hanseatic City of Hamburg, Germany
- Asklepios Klinik Nord - Hamburg, Free and Hanseatic City of Hamburg, Germany
- University Medical Center Göttingen - Göttingen, Lower Saxony, Germany
- Greifswald University Medicine - Greifswald, Mecklenburg-Vorpommern, Germany
- RWTH Aachen University Hospital - Aachen, North Rhine-Westphalia, Germany
- University Hospital Cologne - Cologne, North Rhine-Westphalia, Germany
- University Hospital Essen - Essen, North Rhine-Westphalia, Germany
- Pfalzklinikum Klingenmünster - Klingenmünster, Rhineland-Palatinate, Germany
- University Medical Center Mainz - Mainz, Rhineland-Palatinate, Germany
- Saarland University Medical Center - Homburg, Saarland, Germany
- University of Leipzig Medical Center - Leipzig, Saxony, Germany
- Madical Faculty University Hospital Magdeburg - Magdeburg, Saxony-Anhalt, Germany
- University Hospital Schleswig-Holstein - Kiel, Schleswig-Holstein, Germany
- Charité - Universitätsmedizin Berlin - Berlin, State of Berlin, Germany
- Charité Campus Benjamin Franklin - Berlin, State of Berlin, Germany
- University Hospital Jena - Jena, Thuringia, Germany