Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
Recruiting · NCT07444567 · Interventional (participants receive a specific treatment) · Lead sponsor: AstraZeneca
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The rationale of the roll-over study (ROSY) is to provide continuous access to study treatment for participants who have completed or exited a parent study and are deemed appropriate for continued benralizumab treatment, as judged by the Investigator, while monitoring long-term safety and tolerability of benralizumab.
Who can take part
Age range
6 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- 1\. Provision of signed and dated written ICF.
- \. Participants completing minimum required OLE period of a parent study and judged by the Investigator to benefit from continued treatment.
- 3\. Participants must agree to follow the contraception requirements as per their respective parent protocols from study inclusion up to 12 weeks after the last dose of study treatment.
- 4\. Participants without childbearing potential at enrolment must agree to start appropriate contraception if childbearing potential develops during the study and up to 12 weeks after the last dose of study treatment.
- 5\. Participants who are unable to access commercially available benralizumab and clinically indicated for continuation.
Exclusion criteria
- 1\. Ongoing, unresolved AE requiring interruption of treatment at the end of the prior parent study (ie, when the parent study is either completed or closed) that in the Investigator's opinion would prevent restarting benralizumab.
- 2\. Participants who are planning to use live/live-attenuated vaccines.
- 3\. Participants who are planning to use biologic therapies, including B-cell therapies with the exception for the treatment of co-morbidities where no alternative medicine is available.
- 4\. Participants with any medical condition (such as cancer or viral infections \[hepatitis\]) or psychiatric condition that, in the opinion of the Investigator, could jeopardise or would compromise the participant's ability to participate in this study as determined by the Investigator based on protocol required assessments.
- 5\. Concurrently enrolled in any clinical study (other than a parent study).
- 6\. Participants who discontinued the parent study prior to completing the minimum OLE or treatment period.
- 7\. Local access to commercially available benralizumab.
Where it is running
45 locations listed across 8 US states.
- Research Site - Aurora, Colorado, United States
- Research Site - Bethesda, Maryland, United States
- Research Site - Ann Arbor, Michigan, United States
- Research Site - Northfield, New Jersey, United States
- Research Site - The Bronx, New York, United States
- Research Site - Durham, North Carolina, United States
- Research Site - Cleveland, Ohio, United States
- Research Site - Salt Lake City, Utah, United States
- Research Site - Ahmedabad, India
- Research Site - Ajmer, India
- Research Site - Bron, France
- Research Site - Brussels, Belgium
- Research Site - Buenos Aires, Argentina
- Research Site - Chęciny, Poland
- Research Site - Edegem, Belgium
- Research Site - Florida, Argentina
- Research Site - Gdansk, Poland
- Research Site - Haifa, Israel
- Research Site - Holon, Israel
- Research Site - Incheon, South Korea
- Research Site - Innsbruck, Austria
- Research Site - Istanbul, Turkey (Türkiye)
- Research Site - Lobos, Argentina
- Research Site - Lodz, Poland
- Research Site - Lodz, Poland
- Research Site - London, United Kingdom
- Research Site - Mar del Plata, Argentina
- Research Site - Marseille, France
- Research Site - Mendoza, Argentina
- Research Site - Mendoza, Argentina
- Research Site - Montpellier, France
- Research Site - Nantes, France
- Research Site - Paris, France
- Research Site - Paris, France
- Research Site - Pessac, France
- Research Site - Roma, Italy
- Research Site - Rosario, Argentina
- Research Site - Rotterdam, Netherlands
- Research Site - San Juan Bautista, Argentina
- Research Site - Suresnes, France
- Research Site - Calgary, British Columbia, Canada
- Research Site - Hamilton, Ontario, Canada
- Research Site - Toronto, Ontario, Canada
- Research Site - Toronto, Ontario, Canada
- Research Site - Toronto, Ontario, Canada