Alterations in Mast Cell and Macrophage Infiltration, as Well as Micro Vessel Density
Recruiting · NCT07448896 · Observational (researchers observe without assigning treatment) · Lead sponsor: General Committee of Teaching Hospitals and Institutes, Egypt
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Obesity is a global health problem that has reached epidemic proportions, affecting more than one billion people worldwide and significantly increasing the risk of multiple comorbidities, including type 2 diabetes, cardiovascular diseases, and cancer (World Health Organization, 2024). Increasing evidence suggests that chronic low-grade inflammation associated with obesity plays a critical role in the development of obesity-related malignancies, including gastric cancer. Adipose tissue dysfunction in obesity leads to the recruitment and activation of various immune cells, such as macrophages and mast cells, which contribute to a pro-inflammatory microenvironment through the release of cytokines, growth factors, and angiogenic mediators.
Who can take part
Inclusion criteria
- Adult patients undergoing bariatric surgery (laparoscopic sleeve gastrectomy).
- BMI \> 35 kg/m²
- All participants underwent preoperative evaluation, including blood tests and assessment by a multidisciplinary team (nutritionist, psychiatrist, endocrinologist, radiologist, anesthesiologist, and surgeon).
Exclusion criteria
- Patients with secondary causes of obesity, such as Cushing's syndrome or polycystic ovary syndrome (PCOS).
- Patients with malignant gastric conditions or previous gastric surgery.
- Patients with systemic inflammatory diseases, autoimmune disorders, or chronic infections that may influence immune cell infiltration.
- Patients with incomplete clinical data or poor-quality tissue samples.
- Patients taking anti-inflammatory, immunosuppressive, or corticosteroid therapy within the last 3 months before sampling.
Where it is running
1 location listed.
- The surgical department of Medical Research Institute Hospital, Alexandria University - Alexandria, Alexandria Governorate, Egypt