Mechanisms of Atrial Pathoelectrophysiology in HCM
Recruiting · NCT07454135 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →What this trial is about
This study aims to learn why atrial fibrillation (AF), a type of irregular heartbeat, happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM). HCM is an inherited condition where the heart muscle is thicker than usual. Researchers will study electrical signals from the heart and advanced heart imaging. By doing this, they hope to better understand how AF behaves in people with HCM and why treatments may not work as well for them. The information from this study may help improve future treatments for people who have both HCM and AF.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Paroxysmal or persistent atrial fibrillation
- Diagnosis of hypertrophic cardiomyopathy
- Patient planning to proceed to atrial fibrillation ablation following clinical consultation
- Age 18-80 years
- Able and willing to provide written informed consent
- Able and willing to comply with study follow up requirements
Exclusion criteria
- Any clinical contra-indication to ablation
- Any disease limiting life expectancy to \<1 year
- Potential participant currently pregnant or breast feeding
- Contraindication to MRI including renal dysfunction (eGFR\<30ml/min)
- Unable to understand verbal or written explanations given in English
Where it is running
1 location listed.
- Guy's and St Thomas' NHS Foundation Trust - London, United Kingdom