Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Recruiting · NCT07462000 · Interventional (participants receive a specific treatment) · Lead sponsor: Military Institute od Medicine National Research Institute
View the official record on ClinicalTrials.gov →Interventions studied
Phacoemulsification With Intraocular Lens ImplantationPhacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy
What this trial is about
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 18 years.
- Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation).
- Ability to provide written informed consent.
- For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure.
- For control arm: cataract without glaucoma and without other significant ocular pathology.
Exclusion criteria
- Age \< 18 years.
- Pregnancy or breastfeeding.
- Advanced visual impairment in the study eye (visual aquity worse than counting fingers).
- Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma).
- History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery.
- Active or previous uveitis.
- Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm).
- Inability to comply with study procedures or follow-up visits.
Where it is running
2 locations listed.
- Military Institute of Medicine - National Research Institute - Warsaw, Poland
- University of Warsaw - Warsaw, Poland