Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate
Recruiting · NCT07462065 · Interventional (participants receive a specific treatment) · Lead sponsor: PAEC General Hospital, Islamabad
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Women who meet the study requirements will be enrolled and randomly assigned by a computer system to receive either pioglitazone 30 mg daily or a placebo starting from the second day of their menstrual period for the same duration. All participants will also take clomiphene citrate 150 mg daily from day 3 to day 7 of the menstrual cycle. A transvaginal ultrasound will be performed on day 10 of the menstrual cycle to assess the growth of ovarian follicles, and the number of mature follicles (16-24 mm) will be recorded. If at least one mature follicle measuring 16-24 mm is present and the endometrial thickness is at least 7 mm, an injection of human chorionic gonadotropin (hCG) will be given to trigger ovulation, followed by an intrauterine insemination (IUI) procedure. Participants will be followed until the end of the menstrual cycle, and if the menstrual period is delayed by 5 days, a blood test for β-hCG will be performed to confirm pregnancy. Any side effects during the treatment period, such as swelling, fluid retention, blurred vision, or weight gain, will be recorded.
Who can take part
Inclusion criteria
- Normal hysterosalpingography Normal spermogram Suffering from PCOS Ovarian cysts less than 20mm.
Exclusion criteria
- History of chronic cardiovascular disease Chronic kidney disease Diabetes Thyroid disease Pulmonary disease
Where it is running
1 location listed.
- Pakistan Atomic Energy Commission Hospital - Islamabad, Federal, Pakistan