Heart Rate Variability in Benign Paroxysmal Positional Vertigo
Recruiting · NCT07472998 · Observational (researchers observe without assigning treatment) · Lead sponsor: Istanbul Aydın University
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder. Although the pathophysiology of BPPV is mainly attributed to the displacement of otoconia within the semicircular canals, recent studies suggest that psychological stress and anxiety may be associated with the onset or recurrence of the disease. However, the biological mechanisms underlying this relationship remain poorly understood, and objective evaluation of autonomic nervous system function in patients with BPPV is limited. Heart rate variability (HRV) is a non-invasive method widely used to assess autonomic nervous system activity. Short-term HRV measurements provide information about autonomic balance and vagal tone. In particular, parameters such as the root mean square of successive differences (RMSSD) and the coefficient of variation of RR intervals (COV RR/R) are considered indicators of parasympathetic activity. The aim of this prospective case-control study is to evaluate vagal tone in patients with BPPV using short-term HRV analysis and to compare the findings with age-, sex-, and body mass index-matched healthy controls. Participants will undergo standardized HRV measurements at rest and during controlled breathing. Perceived stress levels will also be assessed using the Perceived Stress Scale (PSS-10). The primary outcomes of the study are RMSSD and the coefficient of variation of RR intervals (COV RR/R), obtained from short-term HRV recordings. These parameters will be compared between BPPV patients and healthy controls, and their associations with perceived stress levels will also be explored. The findings of this study may provide insights into the role of autonomic regulation and stress-related mechanisms in the pathophysiology of BPPV.
Who can take part
Inclusion criteria
- BPPV Group
- Age 18 years or older
- Clinical diagnosis of benign paroxysmal positional vertigo (BPPV) confirmed by positional testing (Dix-Hallpike and/or Roll test) with positional nystagmus
- No known history of cardiac disease
- Ability and willingness to provide written informed consent
- Healthy Control Group
- Age 18 years or older
- No history of vertigo or known vestibular disorder
- Age- and sex-matched to the BPPV group
- No known history of cardiac disease
- Ability and willingness to provide written informed consent
Exclusion criteria
- Age younger than 18 years
- Inability to provide informed consent or impaired mental capacity
- Known arrhythmia, heart failure, ischemic heart disease, or other clinically significant cardiac disorder
- Use of medications that may directly affect heart rate variability, including beta-blockers, non-dihydropyridine calcium channel blockers, antiarrhythmic drugs, digoxin, systemic corticosteroids, centrally acting sympatholytic agents, or psychotropic medications that may influence autonomic balance
- Active infection or systemic inflammatory disease
Where it is running
1 location listed.
- Medicalpark Florya Hospital - Istanbul, Küçükçekmece, Turkey (Türkiye)