Magnetic Resonance Imaging of the Lung: Oncological Applications
Recruiting · NCT07486219 · Observational (researchers observe without assigning treatment) · Lead sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia
View the official record on ClinicalTrials.gov →What this trial is about
Lung neoplasms are characterized by a complex interaction between tumor cells and a variety of resident and infiltrating host elements, secreted factors, and extracellular matrix proteins, collectively referred to as the microenvironment. Nowadays, in the setting of lung cancer, and in particular non-small cell lung cancer (NSCLC), the evaluation of microenvironment characteristics can only be performed by a pathologist and only on histological material. By combining different MRI parameters, it may be possible to create a specific imaging "signature" for the three different immune phenotypes and thus be able to make a distinction based on MRI examination.
Who can take part
Inclusion criteria
- Primary NSCLC of the lung (TNM 8th edition T parameter ≥T1c)
- Biopsy examination of the primary tumor adequate at least for PDL-1 quantification
- Staging CT scan with uncertain N parameter and definite M parameter.
Exclusion criteria
- Absolute contraindications to magnetic resonance imaging or the administration of gadolinium-based contrast agents
Where it is running
1 location listed.
- Fondazione IRCCS Policlinico San Matteo - Pavia, Italy