Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D
Recruiting · NCT07491848 · Observational (researchers observe without assigning treatment) · Lead sponsor: Research Center of Periodontal-Systemic Interactions
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Periodontal disease is a chronic inflammatory condition associated with systemic diseases, highlighting the concept of periodontal medicine. This study aims to investigate the relationship between periodontal inflammation, oral lesions, and hepatitis B+D infection, with or without bulevirtide treatment. Oral-periodontal clinical parameters and targeted inflammatory biomarkers in saliva and gingival crevicular fluid will be evaluated in three groups: patients with hepatitis B+D receiving bulevirtide, patients with hepatitis B+D not receiving bulevirtide, and healthy controls.
Who can take part
Inclusion criteria
- Adults (≥18 years old) capable of providing informed consent.
- For Hepatitis B+D groups: confirmed hepatitis B and D co-infection.
- Bulevirtide group: receiving bulevirtide therapy as prescribed.
- No Bulevirtide group: not receiving bulevirtide.
- For Healthy Control group: systemically healthy adults without hepatitis B or D infection.
- Willingness to undergo oral-periodontal examination, saliva and gingival crevicular fluid collection, and oral cavity photography.
Exclusion criteria
- Patients with other systemic diseases that could influence periodontal health (e.g., uncontrolled diabetes, autoimmune diseases).
- Patients currently receiving other experimental therapies that may affect oral or systemic inflammation.
- Pregnancy or lactation.
- Inability or unwillingness to provide informed consent.
- History of oral or periodontal surgery within the last 6 months that could affect measurements.
Where it is running
2 locations listed.
- Clinical Emergency County Hospital Craiova - Craiova, Romania
- University of Medicine and Pharmacy of Craiova - Craiova, Romania