AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
Recruiting · NCT07503210 · Interventional (participants receive a specific treatment) · Lead sponsor: Novo Nordisk A/S
View the official record on ClinicalTrials.gov →Interventions studied
NNC0487-0111Placebo (matched to NNC0487-0111)
What this trial is about
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Male or female (sex at birth).
- Age 18 years or above at the time of signing the informed consent.
Exclusion criteria
- Glycated haemoglobin (HbA1c) greater than or equal to ≥ 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening.
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP 1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.
Where it is running
60 locations listed across 11 US states.
- Pinnacle Research Group LLC - Anniston, Alabama, United States
- Diablo Clinical Research, Inc. - Walnut Creek, California, United States
- Florida Inst For Clin Res LLC - Orlando, Florida, United States
- Endeavor Health - Skokie, Illinois, United States
- Midwest Inst For Clin Res - Indianapolis, Indiana, United States
- Medication Mgmnt, LLC_Grnsboro - Greensboro, North Carolina, United States
- PMG Research of Wilmington LLC - Wilmington, North Carolina, United States
- UPA Ctr Weight and Eating Dis - Philadelphia, Pennsylvania, United States
- Clinical Res Collaborative - Cumberland, Rhode Island, United States
- North Texas Endocrine Center - Dallas, Texas, United States
- UT Southwestern Med Cntr - Dallas, Texas, United States
- Selma Medical Associates - Winchester, Virginia, United States
- Rainier Clin Res Ctr Inc - Renton, Washington, United States
- EB Flevo Research BV - Almere Stad, Netherlands
- Centro Periferico De Especialidades Bola Azul - Almería, Spain
- Meander MC - Amersfoort, Netherlands
- Rijnstate Ziekenhuis - Arnhem, Netherlands
- Hospital Clinic i Provincial - Barcelona, Spain
- A.O.Universitaria S.ORSOLA-MALPIGHI - U.O.Endocrinologia e Cura - Bologna, Italy
- CIPREC Pueyrredon - Buenos Aires, Argentina
- EMS Healthcare - Cheshire, United Kingdom
- CHU DE CLERMONT-FERRAND-HOPITAL GABRIEL MONTPIED_Service de Nutrition - Clermont-Ferrand, France
- Anima Research Center - Diepenbeek, Belgium
- Wendisch - Dahl Hamburg - DZHW - Hamburg, Germany
- AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie - Kortrijk, Belgium
- CHU GRENOBLE ALPES-SITE NORD MICHALLON_Endocrinologie,diabétologie,maladies de la nutrition - La Tronche, France
- GROUPE SOS SANTE-HOPITAL LE CREUSOT-HOTEL DIEU_ Service de Diabétologie - Le Creusot, France
- Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH - Leipzig, Germany
- H. de León_Endocrinología - León, Spain
- CHU LILLE-HOPITAL CLAUDE HURIEZ_Service de Chirurgie Générale et Endocrinienne - Lille, France
- Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz - Lingen, Germany
- Centre hospitalier universitaire de Liège (CHU de Liège) - Liège, Belgium
- DCC 1 - Lom EOOD - Lom, Bulgaria
- Hospital Clínico San Carlos - Madrid, Spain
- H. Clinico Univ. Virgen de la Victoria - Málaga, Spain
- Institut für Diabetesforschung GmbH Münster - Dr. med. Rose - Münster, Germany
- RED-Institut für medizinische Forschung und Fortbildung GmbH - Oldenburg in Holstein, Germany
- AZ OOSTENDE (Campus DAMIAAN) - Ostend, Belgium
- MHAT Med Line Clinic - Plovdiv, Bulgaria
- UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic - Plovdiv, Bulgaria
- AIPSOMCEMD ENDO MED CONSULT 2020 - Dr. Aleksander Botushanov EOOD - Plovdiv, Bulgaria
- CHU DE POITIERS_Centre d'investigation Clinique - Poitiers, France
- H.U. Quirónsalud Madrid - Pozuelo de Alarcón, Spain
- Clifton Medical Centre - Rotherham, United Kingdom
- IRCCS Humanitas - U.O. Endocrinologia e Diabetologia - Rozzano (MI), Italy
- Zentrum für klinische Studien Alexander Segner - Saint Ingbert-Oberwürzbach, Germany
- Hospital Universitario Virgen del Rocío - Seville, Spain
- SGHAT Dr. Shterev EOOD - Sofia, Bulgaria
- UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases - Sofia, Bulgaria
- Medical Center Maraya Med EOOD - Sofia, Bulgaria
- AIPSMC Dr. Traykovska EOOD - Sofia, Bulgaria
- Staploe Medical Centre - Soham, United Kingdom
- Albany House Medical Centre - Wellingborough, United Kingdom
- Conexa - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
- CICEMO- Consultorio (Av Directorio) - Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
- Instituto de Investigaciones Clinicas Mar Del Plata - Mar del Plata, Buenos Aires, Argentina
- Arcispedale Sant'Anna (Cona) - UO di Endocrinologia - Ferrara, Emilia-Romagna, Italy
- IRCCS Ospedale Policlinico San Martino - Medicina Interna e Specialità Mediche - Genoa, Liguria, Italy
- PreCare Trial & Recruitment - Born, Limburg, Netherlands
- Fondazione Salvatore Maugeri I.R.C.C.S. - Pavia - Dipartimento Medicina Interna e Generale - Pavia, Lombardy, Italy
Showing 60 of 72 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →