Electroacupuncture Plus 5-HT3 Receptor Inhibitor for PONV Prevention in High-Risk Patients Undergoing Thoracoscopic Lung Cancer Surgery
Recruiting · NCT07515027 · Interventional (participants receive a specific treatment) · Lead sponsor: Shanghai Chest Hospital
View the official record on ClinicalTrials.gov →Interventions studied
ElectroacupunctureProphylactic administration of dolasetronSham electroacupuncture
What this trial is about
This prospective, randomized controlled study aims to evaluate the efficacy and safety of electroacupuncture combined with 5-HT3 receptor inhibitor for preventing postoperative nausea and vomiting (PONV) in high-risk patients undergoing thoracoscopic lung cancer surgery. The primary outcome is the incidence of PONV within 24 hours after surgery.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 18 years;
- American Society of Anesthesiologists (ASA) physical status I-III;
- Body mass index (BMI) 18-30 kg/m²;
- Scheduled for elective video-assisted thoracoscopic surgery (VATS) lobectomy, segmentectomy, or wedge resection;
- Expected to receive postoperative opioid analgesia, with an Apfel risk score ≥ 3;
- Normal pulmonary function, without severe cardiovascular, hepatic, or renal abnormalities;
- No infection around the acupuncture sites;
- Voluntary written informed consent provided by the subject.
Exclusion criteria
- Severe systemic diseases, such as cardiovascular, hepatic, or renal abnormalities, or poor pulmonary function;
- Subjects with cognitive dysfunction or psychological disorders;
- History of previous esophageal or gastric surgery;
- Hypersensitivity to acupuncture or any study medications;
- Severe infection or history of surgery around the acupuncture sites;
- Pregnant or lactating women;
- Long-term opioid use;
- Conversion to open surgery;
- Acupuncture treatment received within 1 month prior to enrollment.
Where it is running
1 location listed.
- Shanghai Chest Hospital - Shanghai, China