Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease
Recruiting · NCT07524400 · Interventional (participants receive a specific treatment) · Lead sponsor: Universidad Rey Juan Carlos
View the official record on ClinicalTrials.gov →Interventions studied
ExerciseSham tDCS and exercisereal tDCS and exercise
What this trial is about
A controlled, blinded, and randomized clinical study will be carried out in a large sample of people with Parkinson's disease, where the combined effects of physical exercise and transcranial direct curren stimlation (tDCS) on motor function will be evaluated.
Who can take part
Age range
No age limits stated
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Clinical diagnosis of idiopathic Parkinson's disease, established according to the UK Parkinson's Disease Society Brain Bank Criteria.
- Ability to understand and comply with study procedures.
- Stable antiparkinsonian medication regimen prior to study participation.
Exclusion criteria
- Significant cognitive impairment, defined as a score \< 23 on the Mini-Mental State Examination (MMSE).
- Below-average premorbid intelligence, defined as a score \< 40 on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Third Edition (WAIS-III).
- Clinically significant depression, defined as a score \> 10 on the Geriatric Depression Scale (GDS-15).
- Current treatment with cholinesterase inhibitors.
- Presence of severe cardiovascular disease, including but not limited to:
- Congestive heart failure
- Ischemic heart disease
- Cardiac pacemaker
- rthostatic hypotension
- Uncontrolled diabetes mellitus.
- History of stroke or traumatic brain injury.
- History of seizure disorder or epilepsy.
- Presence or prior implantation of a deep brain stimulation (DBS) device.
- History of major orthopedic surgery that could interfere with motor performance or gait.
- Presence of implanted electronic devices, including cardiac pacemakers, incompatible with study procedures.
Where it is running
1 location listed.
- Center of Sport Research - Fuenlabrada, Madrid, Spain