Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Recruiting · NCT07527156 · Interventional (participants receive a specific treatment) · Lead sponsor: Institute for Clinical and Experimental Medicine
View the official record on ClinicalTrials.gov →Interventions studied
Ketone Monoester (KE)
What this trial is about
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- LVEF \<35%
- Acute heart failure with low cardiac output syndrome or cardiogenic shock
Exclusion criteria
- Severe liver failure
- Severe acidosis
- Inability to insert nasogastric tube
- Gastric paralysis / ileus
- Repeated vomiting
- Severe hypokalemia
Where it is running
1 location listed.
- Institute for Clinical and Experimental Medicine (IKEM) - Prague, Prague, Czechia