The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Recruiting · NCT07539675 · Observational (researchers observe without assigning treatment) · Lead sponsor: Zhongnan Hospital
View the official record on ClinicalTrials.gov →Interventions studied
No Additional Experimental Intervention
What this trial is about
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Who can take part
Age range
50 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Clinically diagnosed with primary angle-closure glaucoma (PACG)
- Aged ≥ 50 years, no gender restriction
- Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
- Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
- Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
Exclusion criteria
- Secondary glaucoma
- History of previous intraocular surgery
- Systemic diseases that can cause abnormal ocular zonules
- Other severe ocular diseases
- Long-term use of medications affecting connective tissue metabolism
Where it is running
1 location listed.
- Zhongnan Hospital of Wuhan University - Wuhan, Hubei, China