The ISAR InflEx Trial (Inflammation and Exercise)
Recruiting · NCT07543666 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
moderate-intensity exerciseshort bouts of maximal exercisevigorous-intensity exercise
What this trial is about
A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.
Who can take part
Age range
18 Years to 45 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- BMI 25.0 - 30.0 kg/m²
- age 18 - 45 years
- informed consent
- no regular physical activity (≤1x/week of structured exercise)
- willingness to strictly follow and adhere to the intervention protocol for the entire study
Exclusion criteria
- any acute or chronic illness
- pregnancy and breastfeeding
- active smoking
- Regular use of medication
Where it is running
1 location listed.
- German Heart Centre - München, Bavaria, Germany