Opportunistic Breast Cancer Screening Using Non-Contrast Chest CT
Recruiting · NCT07557654 · Observational (researchers observe without assigning treatment) · Lead sponsor: Fudan University
View the official record on ClinicalTrials.gov →What this trial is about
The goal of this observational study is to evaluate the feasibility and effectiveness of using non-contrast chest computed tomography scans for opportunistic breast cancer screening, and to further compare its diagnostic performance with conventional imaging modalities, including mammography and/or breast magnetic resonance imaging.
Who can take part
Age range
18 Years and older
Sex
Female
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Female patients who have undergone non-contrast chest CT examination;
- Participants included in the comparative analysis must have undergone at least one comparator imaging modality (mammography and/or breast MRI);
- If a breast lesion is detected, it must be confirmed by pathology or clinical follow-up at least 12 months;
- No prior systemic or local therapy before imaging examinations;
- Imaging data are complete and of sufficient quality for analysis.
Exclusion criteria
- History of other malignancies with potential impact on breast imaging interpretation;
- Participants with suspected malignant breast lesions but no confirmation;
- Prior radiotherapy, chemotherapy, or immunotherapy before imaging examinations;
- Imaging data that are incomplete, of poor quality, or contain significant artifacts preventing reliable analysis;
- Time interval between non-contrast chest CT and comparator imaging modalities exceeding three months, or with clinical events occurring between examinations that may alter lesion status.
Where it is running
1 location listed.
- Fudan University Shanghai Cancer Center - Shanghai, China