A Phase II Trial Evaluating Upfront Stereotactic Body Radiotherapy in Stage III Advanced Non-small Cell Lung Cancer
Recruiting · NCT07565987 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
SBRT in stage III NSCLC
What this trial is about
The aim of the study is to test the feasibility \& loco-regional control rate by combining high precision SBRT with chemotherapy in stage III NSCLC in tumor/lymph nodes if tumors/lymph node size with ≤ 6cms in size.
Who can take part
Age range
18 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Aged 18 or above and less than 75 years.
- Histologically proven non-small cell lung cancer.
- Stage T1-4, N1-3, M0 with maximum tumor size less than 6 cms and ≤ 3 stations of largest lymph node size less than 4 cms.
- ECOG status 0-1.
- Available to attend long term follow- up.
- Written informed consent for treatment.
Exclusion criteria
- Metastatic disease.
- Tumor size \> 6cm.
- Involved Lymph node size greater than 4 cms \& more than 3 station of lymph nodes involved.
- Patients with superior vena cava obstruction.
- Tumor invading/encasing the proximal bronchial tree/, esophagus, pericardium.
- Previous radiotherapy to thorax.
- Small cell histology.
- Age\< 18 or \> 75 years.
- Patients on anticoagulant therapy \& ultra-central cavitary tumors.
- Poor performance status ECOG 2-3.
- Immunocompromised states.
- Viral Markers negative.
- Pregnant women
Where it is running
1 location listed.
- Nci, Aiims-Jhajjar - Jhajjar, Haryana, India