A Study of TRC003 in the Treatment of Patients With Progressive PSMA-positive mCRPC
Recruiting · NCT07567521 · Interventional (participants receive a specific treatment) · Lead sponsor: C Ray Therapeutics
View the official record on ClinicalTrials.gov →Interventions studied
Radiopharmaceuticals
What this trial is about
The purpose of this study is to evaluate safety and tolerability, pharmacokinetics （PK）, efficacy of TRC003 injection in patients with progressive PSMA-positive mCRPC who have been treated with androgen receptor pathway inhibitor (ARPI) or taxane-based chemotherapy. We plan to recruit 90 participants who will be randomly assigned to 1 of 3 dose cohorts (30 cases per dose cohort) with up to 6 cycles of treatment in this study.
Who can take part
Age range
18 Years and older
Sex
Male
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 1, Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Participants must have the ability to understand and sign ICF.
- Participants must have histological, and/or cytological confirmation of adenocarcinoma of the prostate.
- Participants must have progressive mCRPC after treatment of ARPI or taxane-based chemotherapy.
- Participant must have been diagnosed with mCRPC with documented progressive disease.
- Participants must have prior orchiectomy and/or ongoing androgen-deprivation therapy with a castrate level of serum testosterone (\< 50 ng/dL or \< 1.7 nmol/L).
- Participants must have one or more PSMA-positive lesions whose PSMA uptake (SUVmax) is more than 2 fold of the blood pool.
- Participants with an ECOG performance status of 0 - 2.
- Participants must have adequate organ function
- For participants who have partners of childbearing potential: Partner and/or patient must use a method of birth control with adequate barrier protection, deemed acceptable by the principal Investigator during the study and for 6 months after last investigational product administration.
Exclusion criteria
- Participants with mixed histology of prostate cancer (e.g., neuroendocrine).
- Any FDG-positive and PSMA-negative target lesions.
- Any investigational agents and other concurrent chemotherapy, targeted therapy, biologic agents, immunotherapy, radioligand therapy (androgen-deprivation therapy excepted) within 28 days or 5 half-lives prior to day of administration, whichever is longer.
- Previous treatment with any conventional external beam radiotherapy including hemi-body radiation within 6 weeks before enrollment.
- Previous bone-targeted therapy cannot be taken with a stable dose within 4 weeks before enrollment.
- Known hypersensitivity to the components of the study therapy or its analogs.
- Transfusion for the sole purpose of making a participant eligible for study inclusion within 28 days before administration.
- A superscan as seen in the baseline bone scan.
- Concurrent serious (as determined by the Investigator) medical conditions.
- Diagnosed with other malignancies that are expected to alter life expectancy or may interfere with disease assessment.
Where it is running
2 locations listed.
- Fudan University Shanghai Cancer Center - Shanghai, China
- Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Hospital - Taiyuan, Shanxi, China