CHAMP Lung Cancer Screening Program

Recruiting · NCT07572773 · Interventional (participants receive a specific treatment) · Lead sponsor: Jill Kolesar

View the official record on ClinicalTrials.gov →

Interventions studied

DELFI Diagnostics FirstLook Lung Cancer Screening Blood TestLow-Does CT Scan

What this trial is about

The U.S. Preventive Services Task Force recommends annual lung cancer screening (LCS) with low-dose CT for adults aged 50-80 with a ≥20 pack-year smoking history who currently smoke or quit within the past 15 years. Despite insurance coverage, only 17% of eligible Iowans were screened in 2024. Barriers include the complexity of screening and competing demands in primary care. To address these challenges, investigators propose a two-part intervention: a blood-based screening test to simplify LCS and a community pharmacist-led referral program integrated into routine pharmacy care. Eligible patients will be identified at Greenwood Pharmacy in Waterloo, Iowa. Interested individuals will be consented by a pharmacist and engaged in shared decision-making about LCS. Participants may decline screening, complete the DELFI Diagnostics FirstLook lung cancer screening blood test, or pursue CT screening through their primary care physician. Those choosing the blood test will be referred to Cedar Valley Family Medicine. Patients with a positive result will complete a standard shared decision-making visit with their PCP and, if appropriate, undergo confirmatory CT imaging. Patients with a negative result will enter a screening cohort and be re-screened annually for an additional year.

Who can take part

Age range

50 Years to 77 Years

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

aged 50-77
smoking pack-year history of ≥ 20 years
current smoker or quit smoking 15 or less years ago
ability to understand and willingness to sign a written informed consent document

Exclusion criteria

self-report of lung cancer screening in the last 12 months
psychiatric illness/social situations that would limit compliance with study requirements

Where it is running

3 locations listed across 1 US state.

University of Iowa - Iowa City, Iowa, United States
Cedar Valley Primary Care & Walk-In Clinic - Waterloo, Iowa, United States
Greenwood Pharmacy and Compounding Center - Waterloo, Iowa, United States

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →