A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
Recruiting · NCT07589608 · Interventional (participants receive a specific treatment) · Lead sponsor: Eli Lilly and Company
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.
Who can take part
Age range
18 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- See Master Protocol CWMM (NCT06143956) for inclusion criteria
Exclusion criteria
- In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):
- Have type 1 diabetes or type 2 diabetes
- Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
- Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
- Have a history of acute or chronic pancreatitis
- All concomitant medications should be at a stable dose for at least 3 months prior to screening
Where it is running
40 locations listed across 20 US states.
- The Institute for Liver Health II dba Arizona Clinical Trials - Mesa - Chandler, Arizona, United States
- Headlands Research - Scottsdale - Scottsdale, Arizona, United States
- The Institute for Liver Health II dba Arizona Liver Health-Tucson - Tucson, Arizona, United States
- NorCal Medical Research, Inc - Greenbrae, California, United States
- Velocity Clinical Research, Huntington Park - Huntington Park, California, United States
- Peninsula Research Associates - Rolling Hills Estates, California, United States
- Diablo Clinical Research, Inc. - Walnut Creek, California, United States
- Stamford Therapeutics Consortium - Stamford, Connecticut, United States
- New Horizon Research Center - Miami, Florida, United States
- Indago Research & Health Center, Inc - Miami Lakes, Florida, United States
- Suncoast Clinical Research, Inc. - New Port Richey, Florida, United States
- Charter Research - Winter Park - Orlando, Florida, United States
- Charter Research - Lady Lake - The Villages, Florida, United States
- Medical Research Partners - Ammon, Idaho, United States
- Great Lakes Clinical Trials - Ravenswood - Chicago, Illinois, United States
- Cotton O'Neil Diabetes & Endocrinology - Topeka, Kansas, United States
- Monroe Biomedical Research - Louisville - Louisville, Kentucky, United States
- Knownwell - Needham, Massachusetts, United States
- Lucida Clinical Trials - New Bedford, Massachusetts, United States
- Headlands Research - Detroit - Southfield, Michigan, United States
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division - Troy, Michigan, United States
- StudyMetrix Research - City of Saint Peters, Missouri, United States
- Clinvest Headlands Llc - Springfield, Missouri, United States
- Las Vegas Medical Research - Las Vegas, Nevada, United States
- Dent Neurologic Institute - Amherst, New York, United States
- Rochester Clinical Research, LLC - Rochester, New York, United States
- Medication Management - Greensboro, North Carolina, United States
- Monroe Biomedical Research - Monroe, North Carolina, United States
- Lucas Research, Inc - Morehead City, North Carolina, United States
- Lucas Research, Inc. - New Bern, North Carolina, United States
- CTI Clinical Research Center - Cincinnati, Ohio, United States
- Tribe Clinical Research, LLC - Greenville, South Carolina, United States
- Quality Medical Research - Nashville, Tennessee, United States
- IMA Clinical Research Austin - Austin, Texas, United States
- FutureSearch Trials of Dallas - Dallas, Texas, United States
- PlanIt Research, PLLC - Houston, Texas, United States
- Endeavor Clinical Trials - San Antonio, Texas, United States
- Texas Valley Clinical Research - Weslaco, Texas, United States
- Sovah Clinical Research-River District - Danville, Virginia, United States
- Central Washington Health Services Association d/b/a Confluence Health - Wenatchee, Washington, United States