A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
Recruiting · NCT07595549 · Interventional (participants receive a specific treatment) · Lead sponsor: Pfizer
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.
Who can take part
Inclusion criteria
- Aged ≥18 years.
- BMI of: ≥30 kg/m2 or ≥27.0 kg/m2 to \<30.0 kg/m2 and must have at least 1 of the following weight-related co-morbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2D.
Exclusion criteria
- Have a self-reported body weight change greater than 5% within 90 days prior to Screening.
- Diagnosis of type 1 diabetes or any other form of diabetes other than T2D.
- History of acute or chronic pancreatitis.
- Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).
Where it is running
60 locations listed across 14 US states.
- San Fernando Valley Health Institute - Canoga Park, California, United States
- San Fernando Valley Health Institute - Canoga Park, California, United States
- Headlands Research California, LLC - Escondido, California, United States
- Headlands Research California, LLC - Escondido, California, United States
- ImmuniMet, LLC - Modesto, California, United States
- ImmuniMet, LLC - Modesto, California, United States
- Clinical Trials Research - Sacramento, California, United States
- Clinical Trials Research - Sacramento, California, United States
- University Clinical Investigators, Inc. - Tustin, California, United States
- University Clinical Investigators, Inc. - Tustin, California, United States
- Diablo Clinical Research, Inc. - Walnut Creek, California, United States
- Diablo Clinical Research, Inc. - Walnut Creek, California, United States
- Southern California Retina Specialists - West Hills, California, United States
- Southern California Retina Specialists - West Hills, California, United States
- Nature Coast Clinical Research - Crystal River, Florida, United States
- Nature Coast Clinical Research - Crystal River, Florida, United States
- West Coast Eye Institute - Lecanto, Florida, United States
- West Coast Eye Institute - Lecanto, Florida, United States
- South Broward Research - Miramar, Florida, United States
- South Broward Research - Miramar, Florida, United States
- Suncoast Clinical Research, Inc. - New Port Richey, Florida, United States
- West Coast Medical Associates - New Port Richey, Florida, United States
- Suncoast Clinical Research, Inc. - New Port Richey, Florida, United States
- West Coast Medical Associates - New Port Richey, Florida, United States
- Center for Diabetes, Obesity and Metabolism Inc - Pembroke Pines, Florida, United States
- Center for Diabetes, Obesity and Metabolism Inc - Pembroke Pines, Florida, United States
- Cedar Crosse Research Center - Chicago, Illinois, United States
- Northwestern University - Chicago, Illinois, United States
- Cedar Crosse Research Center - Chicago, Illinois, United States
- Northwestern University - Chicago, Illinois, United States
- Endeavor Health - Family Medicine Administration - Evanston, Illinois, United States
- Endeavor Health - Family Medicine Administration - Evanston, Illinois, United States
- Endeavor Health- Endocrinology Research - Skokie, Illinois, United States
- Endeavor Health- Endocrinology Research - Skokie, Illinois, United States
- MediSphere Medical Research Center, LLC - Evansville, Indiana, United States
- MediSphere Medical Research Center, LLC - Evansville, Indiana, United States
- Monroe Biomedical Research - Louisville, Kentucky, United States
- Monroe Biomedical Research - Louisville, Kentucky, United States
- Ascension Saint Agnes Heart Care - Baltimore, Maryland, United States
- Ascension Saint Agnes Heart Care - Baltimore, Maryland, United States
- Aa Mrc Llc - Flint, Michigan, United States
- Aa Mrc Llc - Flint, Michigan, United States
- University Of Nebraska Medical Center - Omaha, Nebraska, United States
- University Of Nebraska Medical Center - Omaha, Nebraska, United States
- Albuquerque Clinical Trials, Inc. - Albuquerque, New Mexico, United States
- Albuquerque Clinical Trials, Inc. - Albuquerque, New Mexico, United States
- Weill Cornell Medicine - Comprehensive Weight Control Center - New York, New York, United States
- Weill Cornell Medicine - Comprehensive Weight Control Center - New York, New York, United States
- Rochester Clinical Research, LLC - Rochester, New York, United States
- Rochester Clinical Research, LLC - Rochester, New York, United States
- Medication Management LLC - Greensboro, North Carolina, United States
- Medication Management LLC - Greensboro, North Carolina, United States
- Accellacare - Wilmington - Wilmington, North Carolina, United States
- Jeffrey Coleman, OD - Wilmington, North Carolina, United States
- Accellacare - Wilmington - Wilmington, North Carolina, United States
- Jeffrey Coleman, OD - Wilmington, North Carolina, United States
- Midwest Eye Center - Cincinnati, Ohio, United States
- Velocity Clinical Research, Mt. Auburn - Cincinnati, Ohio, United States
- Midwest Eye Center - Cincinnati, Ohio, United States
- Velocity Clinical Research, Mt. Auburn - Cincinnati, Ohio, United States
Showing 60 of 100 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →