MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery

Recruiting · NCT07609680 · Interventional (participants receive a specific treatment) · Lead sponsor: Ankara Etlik City Hospital

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Colorectal Cancer

Interventions studied

Cardiac Index-Guided Hemodynamic ManagementMean Arterial Pressure-Guided Hemodynamic Management

What this trial is about

This prospective randomized trial aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing colorectal surgery. Patients will be randomly assigned to receive either mean arterial pressure-guided or cardiac index-guided intraoperative hemodynamic management. Colorectal surgery is a major abdominal procedure associated with prolonged operative times, significant fluid shifts, blood loss, and hemodynamic instability. These factors can contribute to impaired renal perfusion and subsequent postoperative renal dysfunction. Although mean arterial pressure is widely used to guide intraoperative hemodynamic management, blood pressure alone may not adequately reflect systemic blood flow or regional tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy. The primary outcome of the study is the change in serum creatinine levels from the preoperative baseline to 72 hours postoperatively. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, intensive care unit (ICU) and hospital length of stay, and 30-day mortality.

Who can take part

Age range

18 Years to 80 Years

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

Patients aged 18 to 80 years
Patients with American Society of Anesthesiologists physical status II-III
Patients with estimated glomerular filtration rate ≥60 mL/min/1.73 m²
Patients scheduled for colorectal surgery
Patients who provide written informed consent

Exclusion criteria

Patients younger than 18 years or older than 80 years
Patients with estimated glomerular filtration rate \<60 mL/min/1.73 m²
Patients with American Society of Anesthesiologists physical status other than II-III
Patients who refuse to participate in the study
Patients who withdraw consent at any stage of the study

Where it is running

1 location listed.

Ankara Etlik City Hospital - Ankara, Yenimahalle\Ankara, Turkey (Türkiye)

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →