GLP-1 Therapy After Bariatric Surgery in Chinese Patients With Obesity
Recruiting · NCT07633639 · Interventional (participants receive a specific treatment) · Lead sponsor: China-Japan Friendship Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Obese patients exhibit considerable heterogeneity and complex comorbidities, making long-term effective management challenging with monotherapy. While bariatric surgery remains the most effective weight-loss intervention, postoperative weight regain and metabolic deterioration remain significant concerns. glucagon-like peptide-1 receptor agonists (GLP-1RA) offer distinct advantages for weight loss and metabolic control, and their combination with surgery may produce synergistic effects. This study investigates the efficacy and safety of bariatric surgery combined with adjuvant GLP-1 receptor agonist therapy for Chinese patients with obesity.
Who can take part
Inclusion criteria
- Patients undergoing initial laparoscopic sleeve gastrectomy (LSG).
- obesity:BMI ≥30 kg/m².
- Metabolic comorbidities: Diagnosis of metabolic syndrome or type 2 diabetes mellitus (T2DM) meeting standard criteria.
- Age range: 18-60 years (inclusive).
- Informed consent: Willing participation with documented consent.
Exclusion criteria
- Recent GLP-1RA use: Treatment with GLP-1 receptor agonists within 6 months preoperatively.
- Prior bariatric surgery: History of any metabolic/bariatric surgical procedure.
- Postoperative complications: Requiring reoperation for severe complications (e.g., hemorrhage, anastomotic leak).
- Non-indicated candidates: Patients not meeting standard bariatric surgery indications.
- Significant comorbidities:
- Advanced hepatic/renal dysfunction (Child-Pugh C or eGFR \<30 mL/min/1.73m²). 5.2Active malignancy (except non-melanoma skin cancers). 5.3Autoimmune disorders requiring immunosuppression. 5.4Uncontrolled psychiatric conditions (e.g., active psychosis, severe depression).
Where it is running
1 location listed.
- China-Japan Friendship Hospital - Beijing, China