Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
Recruiting · NCT07638176 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
PEEP0PEEP5PEEPi
What this trial is about
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.
Who can take part
Age range
19 Years to 100 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- American Society of Anesthesiologists Physical Status I - III
- The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2
- Lung resection surgery requiring one-lung ventilation for over 60 minutes
- Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr)
- Patient who is diagnosed with intrinsic PEEP during one-lung ventilation
Exclusion criteria
- Large bullae
- Emergency surgery
- Mechanical ventilation before surgery
- Hemodynamic instability before surgery
- Surgery requiring cardiopulmonary bypass
- Pregnancy, breastfeeding patient
- Patient's refusal to participate
- No intrinsic PEEP during one-lung ventilation
Where it is running
1 location listed.
- Samsung Medical Center - Seoul, South Korea